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Vaidyanathan,A et al. (2016)
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells
British Journal of Cancer 2016 Jul
Pattison,M et al. (2016)
TLR and TNFR1 activation of the MKK3/MKK6-p38? axis in macrophages is mediated by TPL-2 kinase
2016 Jul
Previous studies suggested that TLR stimulation of the p38α MAP kinases is mediated by TAK1 activation of MKK3, MKK4 and MKK6. We used quantitative mass spectrometry to monitor TPL-2-dependent protei.... more
Monfort,A et al. (2016)
A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases
Clinical Cancer Research 2016 Jun
Bohm,S et al. (2016)
Neoadjuvant Chemotherapy Modulates the Immune Microenvironment in Metastases of Tubo-Ovarian High-Grade Serous Carcinoma
Clinical Cancer Research 2016 Jun;12
Ranes,M et al. (2016)
A ubiquitylation site in Cockayne syndrome B required for repair of oxidative DNA damage, but not for transcription-coupled nucleotide excision repair.
Nucleic Acids Research 2016 Apr
Cockayne syndrome B (CSB), best known for its role in transcription-coupled nucleotide excision repair (TC-NER), contains a ubiquitin-binding domain (UBD), but the functional connection between protei.... more
pubmed   full text
Brown,P et al. (2016)
N-terminally truncated FOXP1 protein expression and alternate internal FOXP1 promoter usage in normal and malignant B cells.
Haematologica 2016 Apr
Strong FOXP1 protein expression is a poor risk factor in diffuse large B-cell lymphoma and has been linked to an activated B-cell-like subtype, which preferentially expresses short FOXP1 (FOXP1S) prot.... more
pubmed   full text
Wang,Y et al. (2016)
Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation.
Cell reports 2016 Mar
Cockayne syndrome (CS) is a severe neurodevelopmental disorder characterized by growth abnormalities, premature aging, and photosensitivity. Mutation of Cockayne syndrome B (CSB) affects neuronal gene.... more
pubmed   full text
Kantidakis,T et al. (2016)
Mutation of cancer driver MLL2 results in transcription stress and genome instability.
Genes & development 2016 Feb;30;408-20
Genome instability is a recurring feature of tumorigenesis. Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous different cancer types, but the mechanism is unclear. Here, .... more
Kulbe,H et al. (2016)
Integrated transcriptomic and proteomic analysis identifies protein kinase CK2 as a key signaling node in an inflammatory cytokine network in ovarian cancer cells.
Oncotarget 2016 Feb
We previously showed how key pathways in cancer-related inflammation and Notch signaling are part of an autocrine malignant cell network in ovarian cancer. This network, which we named the TNF network.... more
Helft,J et al. (2016)
Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures
Journal of Immunity 2016 Jan;44;3-4
Helft,J et al. (2015)
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells
Journal of Immunity 2015 Jun;1-15
Dendritic cells (DCs) are key players in the immune system. Much of their biology has been elucidated via culture systems in which hematopoietic precur- sors differentiate into DCs under the aegis .... more
pubmed   full text
Schmieg,N et al. (2015)
Novel Kidins220/ARMS splice isoforms: potential specific regulators of neuronal and cardiovascular development
PLOS One 2015 Jun
Kidins220/ARMS is a transmembrane protein playing a crucial role in neuronal and cardiovascular development. Kidins220/ARMS is a downstream target of neurotrophin receptors and interacts with several.... more
pubmed   full text
Jamal-Hanjani,M et al. (2015)
Extreme chromosomal instability forecasts improved outcome in ER-negative breast cancer: a prospective validation cohort study from the TACT trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2015 May
Chromosomal instability (CIN) has been shown to be associated with drug resistance and poor clinical outcome in several cancer types. However, in oestrogen receptor (ER)-negative breast cancer we have.... more
Murugaesu,N et al. (2015)
Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy.
Cancer discovery 2015 May
Esophageal adenocarcinomas (EACs) are associated with dismal prognosis. Deciphering the evolutionary histories of this disease may shed light on therapeutically tractable targets and reveal dynamic mu.... more
D,C et al. (2015)
MiR-19-mediated inhibition of Transglutaminase-2 leads to enhanced invasion and metastasis in colorectal cancer.
Molecular cancer research : MCR 2015 May
Transglutaminase-2 (TG2) is a critical crosslinking enzyme in the extracellular matrix (ECM) and tumor microenvironment (TME). While its expression has been linked to colorectal cancer (CRC), its func.... more
Favero,F et al. (2015)
Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2015 May;26;880-7
Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options. GBM has been shown to predominantly disrupt three c.... more
Cheng,T et al. (2015)
A simple biophysical model emulates budding yeast chromosome condensation.
eLife 2015 Apr;4
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb.... more
Amankwatia ,E et al. (2015)
MicroRNA-224 (miR-224) is associated with colorectal cancer progression and response to 5-fluorouracil-based chemotherapy by KRAS-dependent and independent mechanisms
British Journal of Cancer 2015 Apr;112;1480-1490
Colorectal cancer is a leading cause of both cancer incidence and cancer death. Colorectal cancers arise from benign colorectal adenomas, although not all adenomas progress to cancer - development of .... more
Ling,H et al. (2015)
The clinical and biological significance of MIR-224 expression in colorectal cancer metastasis.
Gut 2015 Mar
MicroRNA (miRNA) expression profile can be used as prognostic marker for human cancers. We aim to explore the significance of miRNAs in colorectal cancer (CRC) metastasis..... more
Ramasubramanyan,S et al. (2015)
Epstein-Barr virus transcription factor Zta acts through distal regulatory elements to directly control cellular gene expression.
Nucleic acids research 2015 Mar
Lytic replication of the human gamma herpes virus Epstein-Barr virus (EBV) is an essential prerequisite for the spread of the virus. Differential regulation of a limited number of cellular genes has b.... more
Bullock,M et al. (2015)
Stratifying risk of recurrence in stage II colorectal cancer using deregulated stromal and epithelial microRNAs.
Oncotarget 2015 Mar
MicroRNAs (miRNAs) enable colonic epithelial cells to acquire malignant characteristics and metastatic capabilities. Recently, cancer relevant miRNAs deregulated during disease progression have also b.... more
Kanu,N et al. (2015)
SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair.
Oncogene 2015 Mar
Defining mechanisms that generate intratumour heterogeneity and branched evolution may inspire novel therapeutic approaches to limit tumour diversity and adaptation. SETD2 (Su(var), Enhancer of zeste,.... more
Diefenbacher,M et al. (2015)
Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer.
Cancer research 2015 Feb
The stability of several oncoproteins, including c-Myc, is regulated by ubiquitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase. This activity is antagonized by the deubiquitinase U.... more
Lewis,C et al. (2015)
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme.
Oncogene 2015 Jan
Oxygen and nutrient limitation are common features of the tumor microenvironment and are associated with cancer progression and induction of metastasis. The inefficient vascularization of tumor tissue.... more
Niavarani,A et al. (2015)
APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts.
PloS one 2015 Jan;10;e0120089
Classic deamination mRNA changes, including cytidine to uridine (C-to-U) and adenosine to inosine (A-to-I), are important exceptions to the central dogma and lead to significant alterations in gene tr.... more
, et al. (2015)
Recurrent chromosomal gains and heterogeneous driver mutations characterise papillary renal cancer evolution.
Nature communications 2015 Jan;6;6336
Papillary renal cell carcinoma (pRCC) is an important subtype of kidney cancer with a problematic pathological classification and highly variable clinical behaviour. Here we sequence the genomes or ex.... more
Pender,A et al. (2015)
Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach.
PloS one 2015 Jan;10;e0139074
Droplet digital PCR (ddPCR) can be used to detect low frequency mutations in oncogene-driven lung cancer. The range of KRAS point mutations observed in NSCLC necessitates a multiplex approach to effic.... more
East,P et al. (2014)
Meta-analysis of prostate cancer gene expression data identifies a novel discriminatory signature enriched for glycosylating enzymes.
BMC medical genomics 2014 Dec;7;513
BackgroundTumorigenesis is characterised by changes in transcriptional control. Extensive transcript expression data have been acquired over the last decade and used to classify prostate cancers. Pros.... more
Rushworth,L et al. (2014)
Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Proceedings of the National Academy of Sciences of the United States of America 2014 Dec;111;18267-72
Ectopic expression of dual-specificity phosphatase 5 (DUSP5), an inducible mitogen-activated protein (MAP) kinase phosphatase, specifically inactivates and anchors extracellular signal-regulated kinas.... more
Andre,F et al. (2014)
Prioritizing targets for precision cancer medicine.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2014 Dec;25;2295-2303
The implementation of cancer genomic testing into the clinical setting has brought major opportunities. However, as our understanding of cancer initiation, maintenance and progression improves through.... more
de Bruin,E et al. (2014)
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution.
Science (New York, N.Y.) 2014 Oct;346;251-6
Spatial and temporal dissection of the genomic changes occurring during the evolution of human non-small cell lung cancer (NSCLC) may help elucidate the basis for its dismal prognosis. We sequenced 25.... more
Lonnstedt,I et al. (2014)
Deciphering clonality in aneuploid tumors using SNP array and sequencing data.
Genome biology 2014 Oct;15;470
Intra-tumor heterogeneity concerns the existence of genetically different subclones within the same tumor. Single sample quantification of heterogeneity relies on precise determination of chromosomal .... more
diMartino,E et al. (2014)
Alteration of Cell-Cell and Cell-Matrix Adhesion in Urothelial Cells: an Oncogenic Mechanism for Mutant FGFR3.
Molecular cancer research : MCR 2014 Sep
Activating mutations in fibroblast growth factor receptor 3 (FGFR3) are a common and early event in bladder cancer. Ectopic expression of mutant FGFR3 in normal urothelial cells has both pro-prolifera.... more
Lopez-Serra,L et al. (2014)
The Scc2-Scc4 complex acts in sister chromatid cohesion and transcriptional regulation by maintaining nucleosome-free regions.
Nature genetics 2014 Aug
The cohesin complex is at the heart of many chromosomal activities, including sister chromatid cohesion and transcriptional regulation. Cohesin loading onto chromosomes depends on the Scc2-Scc4 cohesi.... more
Fisher,R et al. (2014)
Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution
Genome Biology 2014 Aug;15;433
Background Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution. Results We perform whole e.... more
Chandler,H et al. (2014)
Role of Polycomb Group Proteins in the DNA Damage Response - A Reassessment.
PloS One 2014 Jul;9;e102968
A growing body of evidence suggests that Polycomb group (PcG) proteins, key regulators of lineage specific gene expression, also participate in the repair of DNA double-strand breaks (DSBs) but eviden.... more
Sawers,L et al. (2014)
Glutathione S-transferase P1 (GSTP1) directly influences platinum drug chemosensitivity in ovarian tumour cell lines
British Journal of Cancer 2014 Jul
Background:Chemotherapy response in ovarian cancer patients is frequently compromised by drug resistance, possibly due to altered drug metabolism. Platinum drugs are metabolised by glutathione S-trans.... more
pubmed   full text
Jamal-Hanjani,M et al. (2014)
Tracking genomic cancer evolution for precision medicine: the lung TRACERx study.
PLoS biology 2014 Jul;12;e1001906
The importance of intratumour genetic and functional heterogeneity is increasingly recognised as a driver of cancer progression and survival outcome. Understanding how tumour clonal heterogeneity impa.... more
Saponaro,M et al. (2014)
RECQL5 Controls Transcript Elongation and Suppresses Genome Instability Associated with Transcription Stress.
Cell 2014 May
RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome sta.... more
Esnault,C et al. (2014)
Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts.
Genes & development 2014 May;28;943-58
The transcription factor SRF (serum response factor) recruits two families of coactivators, the MRTFs (myocardin-related transcription factors) and the TCFs (ternary complex factors), to couple gene t.... more
Gerlinger,M et al. (2014)
Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing.
Nature genetics 2014 Mar;46;225-33
Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten c.... more
Deddouche,S et al. (2014)
Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells
Elife 2014 Feb
The RIG-I-like receptors RIG-I, LGP2, and MDA5 initiate an antiviral response that includes production of type I interferons (IFNs). The nature of the RNAs that trigger MDA5 activation in infected cel.... more
pubmed   full text
Hayashi,R et al. (2014)
A Genetic Screen Based on In Vivo RNA Imaging Reveals Centrosome-Independent Mechanisms for Localizing gurken Transcripts in Drosophila.
G3 (Bethesda, Md.) 2014 Feb
We have screened chromosome arm 3L for EMS-induced mutations that disrupt localization of fluorescently-labeled gurken (grk) mRNA, whose transport along MTs establishes both major body axes of the dev.... more
Luxton,H et al. (2014)
Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.
Molecular oncology 2014 Jan
The pivotal role of LYRIC/AEG-1 in malignant transformation, tumourigenesis and chemo-resistance has previously been demonstrated in different cell types and sub-cellular compartments. The localisatio.... more
Wang,Y et al. (2014)
Dysregulation of gene expression as a cause of Cockayne syndrome neurological disease.
Proceedings of the National Academy of Sciences of the United States of America 2014 Jan
Cockayne syndrome (CS) is a multisystem disorder with severe neurological symptoms. The majority of CS patients carry mutations in Cockayne syndrome group B (CSB), best known for its role in transcrip.... more
Kumar,M et al. (2014)
HMGA2 functions as a competing endogenous RNA to promote lung cancer progression.
Nature 2014 Jan;505;212-7
Non-small-cell lung cancer (NSCLC) is the most prevalent histological cancer subtype worldwide. As the majority of patients present with invasive, metastatic disease, it is vital to understand the bas.... more
Roden,D et al. (2014)
ZODET: software for the identification, analysis and visualisation of outlier genes in microarray expression data.
PloS one 2014 Jan;9;e81123
Complex human diseases can show significant heterogeneity between patients with the same phenotypic disorder. An outlier detection strategy was developed to identify variants at the level of gene tran.... more
Pemberton,H et al. (2014)
Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts.
Genome biology 2014 Jan;15;R23
Polycomb group proteins form multicomponent complexes that are important for establishing lineage-specific patterns of gene expression. Mammalian cells encode multiple permutations of the prototypic P.... more
Bullock,M et al. (2014)
Molecular profiling of the invasive tumor microenvironment in a 3-dimensional model of colorectal cancer cells and ex vivo fibroblasts.
Journal of visualized experiments : JoVE 2014 Jan
Invading colorectal cancer (CRC) cells have acquired the capacity to break free from their sister cells, infiltrate the stroma, and remodel the extracellular matrix (ECM). Characterizing the biology o.... more
Ellis,R et al. (2013)
Prognostic impact of p62 expression in cutaneous malignant melanoma.
Journal of Investigative Dermatology 2013 Dec; 134;1476–1478
Accumulating evidence suggests autophagy, the principle catabolic process for lysosomal degradation of surplus macromolecules (Roy and Debnath, 2010), is fundamental to tumorigenesis. Impaired autopha.... more
pubmed   full text
Horswell,S et al. (2013)
CDKN2B Expression in Adipose Tissue of Familial Combined Hyperlipidaemia Patients.
Journal of lipid research 2013 Oct
The purpose of this study was to determine the core biological processes perturbed in the subcutaneous adipose tissue of Familial Combined Hyperlipidemia (FCHL) patients. Annotation of FCHL and contro.... more
Rouault-Pierre,K et al. (2013)
HIF-2? Protects Human Hematopoietic Stem/ Progenitors and Acute Myeloid Leukemic Cells from Apoptosis Induced by Endoplasmic Reticulum Stress.
Cell stem cell 2013 Oct
Hematopoietic stem and progenitor cells (HSPCs) are exposed to low levels of oxygen in the bone marrow niche, and hypoxia-inducible factors (HIFs) are the main regulators of cellular responses to oxyg.... more
Harding,J et al. (2013)
Small RNA profiling of Xenopus embryos reveals novel miRNAs and a new class of small RNAs derived from intronic transposable elements.
Genome research 2013 Sep
Small RNA control of gene expression is critical for developmental processes in vertebrate embryos. To determine the dynamics of small RNA expression and to uncover novel small RNAs in the early verte.... more
Ehrensberger,A et al. (2013)
Mechanistic Interpretation of Promoter-Proximal Peaks and RNAPII Density Maps.
Cell 2013 Aug;154;713-5
Zhang,L et al. (2013)
miR-153 supports colorectal cancer progression via pleiotropic effects that enhance invasion and chemotherapeutic resistance.
Cancer research 2013 Aug
While microRNAs (miRNAs) have been broadly studied in cancer, comparatively less is understood about their role in progression. Here we report that miR-153 has a dual role during progression of colore.... more
Williamson,S et al. (2013)
Characterisations of human prostate stem cells reveal deficiency in class I UGT enzymes as a novel mechanism for castration-resistant prostate cancer.
British journal of cancer 2013 Jul
Background:Evidence increasingly supports that prostate cancer is initiated by the malignant transformation of stem cells (SCs). Furthermore, many SC-signalling pathways are shown to be shared in pros.... more
Hart,R et al. (2013)
The kindlin 3 PH domain has an essential role in integrin LFA-1-mediated B cell adhesion and migration
Journal of Biological Chemistry 2013 Apr
Background:Kindlin 3 is mutated in LAD_III causing widespread infection, but its role in leukocyte function is incompletely understood. Results:Deletion of the PH domain removes kindlin3 from lymphoc.... more
pubmed   full text
Bullock,M et al. (2013)
Pleiotropic actions of miR-21 highlight the critical role of deregulated stromal microRNAs during colorectal cancer progression.
Cell death & disease 2013 Jan;4;e684
The oncogene microRNA-21 (miRNA; miR-21) is overexpressed in most solid organ tumours; however, a recent examination of stage II colorectal cancer (CRC) specimens suggests this may be a stromal phenom.... more
Griffiths,B et al. (2013)
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth.
Cancer & metabolism 2013 Jan;1;3
Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of.... more
Lopez-Serra,L et al. (2012)
Budding Yeast Wapl Controls Sister Chromatid Cohesion Maintenance and Chromosome Condensation.
Current biology : CB 2012 Dec
The establishment of stable sister chromatid cohesion during DNA replication requires acetylation of the chromosomal cohesin complex by the replication fork-associated acetyltransferase Eco1 [1-8]. Co.... more
Horswell,S et al. (2012)
Cancer heterogeneity and
Cancer letters 2012 Nov
The notions of inter- and intra-tumour heterogeneity (ITH) have been recognised for many years but recent advances in sequencing technology are allowing the true extent of both forms of heterogeneity .... more
Jones,D et al. (2012)
Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice.
Disease models & mechanisms 2012 Nov
Cellular ribosomal protein L29 (RPL29) is known to be important in protein synthesis, but its function during angiogenesis has never been described before. We have shown previously that mice lacking ?.... more
Jones,D et al. (2012)
Gene expression analysis in human breast cancer associated blood vessels.
PloS one 2012 Oct;7;e44294
Angiogenesis is essential for solid tumour growth, whilst the molecular profiles of tumour blood vessels have been reported to be different between cancer types. Although presently available anti-angi.... more
Arthur-Farraj,P et al. (2012)
c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration.
Neuron 2012 Aug;75;633-47
The radical response of peripheral nerves to injury (Wallerian degeneration) is the cornerstone of nerve repair. We show that activation of the transcription factor c-Jun in Schwann cells is a global .... more
Steckel,M et al. (2012)
Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies.
Cell research 2012 May
Oncogenic mutations in RAS genes are very common in human cancer, resulting in cells with well-characterized selective advantages, but also less well-understood vulnerabilities. We have carried out a .... more
Kumar,M et al. (2012)
The GATA2 Transcriptional Network Is Requisite for RAS Oncogene-Driven Non-Small Cell Lung Cancer.
Cell 2012 Apr;149;642-55
Non-small cell lung cancer (NSCLC) is the most frequent cause of cancer deaths worldwide; nearly half contain mutations in the receptor tyrosine kinase/RAS pathway. Here we show that RAS-pathway mutan.... more
Ros,S et al. (2012)
Functional metabolic screen identifies 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 as an important regulator of prostate cancer cell survival.
Cancer discovery 2012 Apr;2;328-43
Alterations in metabolic activity contribute to the proliferation and survival of cancer cells. We investigated the effect of siRNA-mediated gene silencing of 222 metabolic enzymes, transporters, and .... more
Salm,M et al. (2012)
The origin, global distribution, and functional impact of the human 8p23 inversion polymorphism.
Genome research 2012 Mar
Genomic inversions are an increasingly recognized source of genetic variation. However, a lack of reliable high-throughput genotyping assays for these structures has precluded a full understanding of .... more
Close,P et al. (2012)
DBIRD complex integrates alternative mRNA splicing with RNA polymerase II transcript elongation.
Nature 2012 Mar
Alternative messenger RNA splicing is the main reason that vast mammalian proteomic complexity can be achieved with a limited number of genes. Splicing is physically and functionally coupled to transc.... more
Gerlinger,M et al. (2012)
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
The New England journal of medicine 2012 Mar;366;883-92
Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples..... more
Gerlinger,M et al. (2012)
Genome-wide RNA interference analysis of renal carcinoma survival regulators identifies MCT4 as a Warburg effect metabolic target.
The Journal of pathology 2012 Feb
Clear cell renal cell carcinoma (ccRCC) is the most common pathological subtype of kidney cancer. Here, we integrated an unbiased genome-wide RNA interference screen for ccRCC survival regulators with.... more
Archibald,K et al. (2012)
Sequential genetic change at the TP53 and chemokine receptor CXCR4 locus during transformation of human ovarian surface epithelium.
Oncogene 2012 Jan
Early genetic events in the development of high-grade serous ovarian cancer (HGSOC) may define the molecular basis of the profound structural and numerical instability of chromosomes in this disease. .... more
pubmed   full text
Lewis,A et al. (2012)
The C-terminus of Apc does not influence intestinal adenoma development or progression.
The Journal of pathology 2012 Jan;226;73-83
Adenomatous polyposis coli (APC ) mutations are found in most colorectal tumours. These mutations are almost always protein-truncating, deleting both central domains that regulate Wnt signalling and C.... more
Ferber,E et al. (2011)
FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression.
Cell death and differentiation 2011 Dec
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase/Akt pathway, and are key regulators of the cell cycle, apoptosis and response to oxidat.... more
Henderson,C et al. (2011)
Increased skin papilloma formation in mice lacking glutathione transferase GSTP.
Cancer Research 2011 Oct
The glutathione transferase GSTP is overexpressed in many human cancers and chemotherapy-resistant cancer cells, where there is evidence that GSTP may have additional functions beyond its known cataly.... more
Dodding,M et al. (2011)
A kinesin-1 binding motif in vaccinia virus that is widespread throughout the human genome.
The EMBO journal 2011 Sep
Transport of cargoes by kinesin-1 is essential for many cellular processes. Nevertheless, the number of proteins known to recruit kinesin-1 via its cargo binding light chain (KLC) is still quite small.... more
Sanz-Moreno,V et al. (2011)
ROCK and JAK1 Signaling Cooperate to Control Actomyosin Contractility in Tumor Cells and Stroma.
Cancer cell 2011 Aug;20;229-45
Proinflammatory cytokines are frequently observed in the tumor microenvironment, and chronic inflammation is involved in cancer initiation and progression. We show that cytokine signaling through the .... more
Staresincic,L et al. (2011)
GTP-dependent binding and nuclear transport of RNA polymerase II by NPA3.
The Journal of biological chemistry 2011 Aug
We identified XAB1 in a proteomic screen for factors that interact with human RNA polymerase II (RNAPII). Since XAB1 has a conserved Saccharomyces cerevisiae homologue called Npa3, yeast genetics and .... more
Coward,J et al. (2011)
Interleukin-6 as a therapeutic target in human ovarian cancer.
Clinical Cancer Research 2011 Jul
PURPOSE: We investigated whether inhibition of IL-6 has therapeutic activity in ovarian cancer via abrogation of a tumor-promoting cytokine network. EXPERIMENTAL DESIGN: We combined pre-clinical an.... more
pubmed   full text
Collazos,A et al. (2011)
Site recognition and substrate screens for PKN family proteins.
The Biochemical journal 2011 Jul
The protein kinase C related kinases (PRKs also referred to as PKNs) are a kinase family important in diverse functions including migration and cytokinesis. Here, we have re-evaluated and compared spe.... more
Mourao-Sa,D et al. (2011)
CLEC-2 signaling via Syk in myeloid cells can regulate inflammatory responses
European Journal of Immunology 2011 Jul;41
Myeloid cells express a plethora of C-type lectin receptors (CLRs) that can regulate immune responses. CLEC-2 belongs to the Dectin-1 sub-family of CLRs that possess an extracellular C-type lectin-l.... more
pubmed   full text
Gadaleta,E et al. (2011)
A global insight into a cancer transcriptional space using pancreatic data: importance, findings and flaws.
Nucleic acids research 2011 Jun
Despite the increasing wealth of available data, the structure of cancer transcriptional space remains largely unknown. Analysis of this space would provide novel insights into the complexity of cance.... more
East,P et al. (2011)
Role of Elongator Subunit Elp3 in Drosophila melanogaster Larval Development and Immunity.
Genetics 2011 Apr;187;1067-75
The Elongator complex has been implicated in several cellular processes, including gene expression and tRNA modification. We investigated the biological importance of the Elp3 gene in Drosophila melan.... more
Lawson,A et al. (2011)
RAF gene fusion breakpoints in pediatric brain tumors are characterized by significant enrichment of sequence microhomology.
Genome research 2011 Mar
Gene fusions involving members of the RAF family of protein kinases have recently been identified as characteristic aberrations of low-grade astrocytomas, the most common tumors of the central nervous.... more
Anglesio,M et al. (2011)
Clinicial Cancer Research 2011 Feb
PURPOSE: Ovarian clear cell adenocarcinoma (OCCA) is an uncommon histotype that is generally refractory to platinum-based chemotherapy. We analyse here the most comprehensive gene expression and copy .... more
pubmed   full text
Lee,A et al. (2011)
CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.
The Journal of pathology 2011 Jan
Chromosomal instability (CIN) has been implicated in multidrug resistance and the silencing of the ceramide transporter, CERT, promotes sensitisation to diverse cytotoxics. An improved understanding o.... more
Ashrafian,H et al. (2010)
Expression profiling in progressive stages of fumarate-hydratase deficiency: the contribution of metabolic changes to tumorigenesis.
Cancer research 2010 Nov;70;9153-65
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that pseudohypoxic stabilization of hypoxia-in.... more
Bilsland,L et al. (2010)
Deficits in axonal transport precede ALS symptoms in vivo.
Proceedings of the National Academy of Sciences of the United States of America 2010 Nov
ALS is a fatal neurodegenerative disease characterized by selective motor neuron death resulting in muscle paralysis. Mutations in superoxide dismutase 1 (SOD1) are responsible for a subset of familia.... more
Ribeiro,P et al. (2010)
Combined Functional Genomic and Proteomic Approaches Identify a PP2A Complex as a Negative Regulator of Hippo Signaling.
Molecular cell 2010 Aug;39;521-534
The Hippo (Hpo) pathway is a central determinant of tissue size in both Drosophila and higher organisms. The core of the pathway is a kinase cascade composed of an upstream kinase Hpo (MST1/2 in mamma.... more
Clear,A et al. (2010)
Increased angiogenic sprouting in poor prognosis FL is associated with elevated numbers of CD163+ macrophages within the immediate sprouting micro-environment.
Blood 2010 Apr
Follicular lymphoma (FL) has considerable clinical heterogeneity and there is a need for easily quantifiable prognostic biomarkers. Micro-vessel density (MVD) has been shown to be a useful prognostic .... more
McDowall,A et al. (2010)
Two mutations in the KINDLIN3 gene of a new leukocyte adhesion deficiency-III patient reveal distinct effects on leukocyte function in vitro.
Blood 2010 Mar
In the disorder Leukocyte Adhesion Deficiency (LAD)-III, integrins on platelets and leukocytes are expressed but fail to function and this leads to severe bleeding and infections at an early age. Muta.... more
Purdie,K et al. (2010)
High-resolution genomic profiling of human papillomavirus-associated vulval neoplasia.
British journal of cancer 2010 Mar;102;1044-51
BACKGROUND: The incidence of human papillomavirus-associated vulval neoplasia is increasing worldwide; yet the associated genetic changes remain poorly understood. METHODS: We have used single-nucleot.... more
Andreassi,C et al. (2010)
An NGF-responsive element targets myo-inositol monophosphatase-1 mRNA to sympathetic neuron axons.
Nature neuroscience 2010 Jan
mRNA localization is an evolutionary conserved mechanism that underlies the establishment of cellular polarity and specialized cell functions. To identify mRNAs localized in subcellular compartments o.... more
Echave,P et al. (2009)
Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.
Journal of cell science 2009 Dec;122;4516-25
Cells generate new organelles when stimulated by extracellular factors to grow and divide; however, little is known about how growth and mitogenic signalling pathways regulate organelle biogenesis. Us.... more
Ramsay,A et al. (2009)
Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy.
Blood 2009 Nov;114;4713-20
An important hallmark of cancer progression is the ability of tumor cells to evade immune recognition. Understanding the relationship between neoplastic cells and the immune microenvironment should fa.... more
Charles,K et al. (2009)
The tumor-promoting actions of TNF-alpha involve TNFR1 and IL-17 in ovarian cancer in mice and humans
Journal of Clinical Investigation 2009 Sep
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine TNF-alpha is an important component of this inte.... more
Le,R et al. (2009)
Peripheral blood T cells in AML patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts.
Blood 2009 Aug
Understanding how the immune system in patients with cancer interacts with malignant cells is critical for the development of successful immunotherapeutic strategies. We studied peripheral blood from .... more
Packer,L et al. (2009)
Identification of direct transcriptional targets of BRAF/MEK signalling in melanoma.
Pigment cell & melanoma research 2009 Aug
Abstract Oncogenic mutations in BRAF are common in melanoma and drive constitutive activation of the MEK/ERK pathway. To elucidate the transcriptional events downstream of (V600E)BRAF/MEK signalling w.... more
Tuupanen,S et al. (2009)
The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.
Nature genetics 2009 Aug;41;885-90
Homozygosity for the G allele of rs6983267 at 8q24 increases colorectal cancer (CRC) risk approximately 1.5 fold. We report here that the risk allele G shows copy number increase during CRC developmen.... more
Lister,T et al. (2009)
Array-based DNA methylation profiling in follicular lymphoma.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2009 Jul
Quantitative methylation profiling was performed using the Illumina GoldenGate Assay in untreated follicular lymphoma (FL) (164), paired pre- and post-transformation FL (20), benign haematopoietic (24.... more
Jwong,K et al. (2009)
An antagonist of the chemokine receptor CXCR4 induces mitotic catastrophe in ovarian cancer cells.
Molecular Cancer Therapy 2009 Jul;8;1893
The chemokine receptor CXCR4 is expressed by malignant cells in ovarian cancer and is implicated in their growth and spread. We report here a unique mechanism of action of a small peptide antagonist o.... more
Swanton,C et al. (2009)
Chromosomal instability determines taxane response.
Proceedings of the National Academy of Sciences of the United States of America 2009 May;106;8671-6
Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in re.... more
Selth,L et al. (2009)
An Rtt109-independent role for Vps75 in transcription-associated nucleosome dynamics.
Molecular and cellular biology 2009 May
The histone chaperone Vps75 forms a complex with, and stimulates the activity of, the histone acetyltransferase Rtt109. However, Vps75 can also be isolated on its own and might therefore possess Rtt10.... more
Schmidt,C et al. (2009)
Conserved features of cohesin binding along fission yeast chromosomes.
Genome biology 2009 May;10;R52
ABSTRACT: BACKGROUND: Cohesin holds sister chromatids together to enable their accurate segregation in mitosis. How, and where, cohesin binds to chromosomes are still poorly understood, and recent gen.... more
ORiain,C et al. (2009)
Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation.
Blood 2009 Mar;113;2298-301
Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was per.... more
Klupsch,K et al. (2009)
Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response.
Cell death and differentiation 2009 Mar;16;449-64
Cellular stress responses can be activated following functional defects in organelles such as mitochondria and the endoplasmic reticulum. Mitochondrial dysfunction caused by loss of the serine proteas.... more
Pollard,P et al. (2009)
The Apc(1322T) mouse develops severe polyposis associated with sub-maximal nuclear beta-catenin expression.
Gastroenterology 2009 Feb
BACKGROUND & AIMS:: We previously demonstrated that the two APC mutations in human colorectal tumours are co-selected, because tumorigenesis requires an optimal level of Wnt signalling. We and others .... more
Purdie,K et al. (2009)
Single Nucleotide Polymorphism Array Analysis Defines a Specific Genetic Fingerprint for Well-Differentiated Cutaneous SCCs.
The Journal of investigative dermatology 2009 Jan
Cutaneous squamous cell carcinomas (cSCCs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cSCC tumorigenesis.... more
Howarth,K et al. (2009)
A mitotic recombination map proximal to the APC locus on chromosome 5q and assessment of influences on colorectal cancer risk.
BMC medical genetics 2009 Jan;10;54
BACKGROUND: Mitotic recombination is important for inactivating tumour suppressor genes by copy-neutral loss of heterozygosity (LOH). Although meiotic recombination maps are plentiful, little is known.... more
Jones,A et al. (2008)
mRNA expression profiling of phyllodes tumours of the breast: identification of genes important in the development of borderline and malignant phyllodes tumours.
The Journal of pathology 2008 Dec;216;408-417
The aim of this study was to identify genes involved in the development of borderline and malignant phyllodes tumours of the breast (PTs). Expression profiling of 23 PTs (12 benign, 11 borderline/mali.... more
East,P et al. (2008)
Concordance of exon array and real-time PCR assessment of gene expression following cancer cell cytotoxic drug exposure.
Cell cycle (Georgetown, Tex.) 2008 Dec;7
Jorissen,R et al. (2008)
DNA copy-number alterations underlie gene expression differences between microsatellite stable and unstable colorectal cancers.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Dec;14;8061-9
PURPOSE: About 15% of colorectal cancers harbor microsatellite instability (MSI). MSI-associated gene expression changes have been identified in colorectal cancers, but little overlap exists between s.... more
Pittman,A et al. (2008)
Refinement of the basis and impact of common 11q23.1 variation to the risk of developing colorectal cancer.
Human molecular genetics 2008 Dec;17;3720-7
The common single-nucleotide polymorphism (SNP) rs3802842 at 11q23.1 has recently been reported to be associated with risk of colorectal cancer (CRC). To examine this association in detail we genotype.... more
Connolly,K et al. (2008)
Stable XIAP knockdown clones of HCT116 colon cancer cells are more sensitive to TRAIL, taxanes and irradiation in vitro.
Cancer chemotherapy and pharmacology 2008 Nov
PURPOSE: To develop a model of X-linked inhibitor of apoptosis (XIAP) down regulation in colorectal cancer cell lines. This may be used to determine whether combination strategies have clinical potent.... more
Houlston,R et al. (2008)
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
Nature genetics 2008 Nov
Genome-wide association (GWA) studies have identified multiple loci at which common variants modestly influence the risk of developing colorectal cancer (CRC). To enhance power to identify additional .... more
London,T et al. (2008)
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts.
The Journal of biological chemistry 2008 Oct
Fanconi anemia (FA) is a heritable human cancer-susceptibility disorder, delineating a genetically heterogenous pathway for the repair of replication-blocking lesions such as interstrand DNA crosslink.... more
Ottaviani,D et al. (2008)
Reconfiguration of genomic anchors upon transcriptional activation of the human major histocompatibility complex.
Genome research 2008 Oct
The folding of chromatin into topologically constrained loop domains is essential for genomic function. We have identified genomic anchors that define the organization of chromatin loop domains across.... more
Milicic,A et al. (2008)
Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo.
Cancer research 2008 Oct;68;7760-8
P-cadherin is normally expressed in the basal layer of squamous epithelia and absent from the healthy intestine and colon. We have previously shown it to be expressed in all inflamed, hyperplastic, an.... more
Gupta,M et al. (2008)
Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia
Genes, Chromosomes & Cancer 2008 Sep;47;729-39
The acquisition of uniparental disomy (aUPD) in acute myeloid leukemia (AML) results in homozygosity for known gene mutations. Uncovering novel regions of aUPD has the potential to identify previously.... more
pubmed   full text
McKinnon,C et al. (2008)
The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells.
Oncogene 2008 Sep
The Rho family of small GTPases control cell migration, cell invasion and cell cycle. Many of these processes are perturbed in cancer and several family members show altered expression in a number of .... more
D’Ambrosio,C et al. (2008)
Identification of cis-acting sites for condensin loading onto budding yeast chromosomes.
Genes & Development 2008 Aug;22;2215–2227
Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin asso.... more
Raghavan,M et al. (2008)
Segmental Uniparental Disomy Is a Commonly-Acquired Genetic Event in Relapsed Acute Myeloid Leukemia
Blood 2008 Aug;112;814-21
Despite advances in the curative treatment of acute myeloid leukemia (AML), recurrence will occur in the majority of cases. At diagnosis, acquisition of segmental uniparental disomy (UPD) by mitotic r.... more
pubmed   full text
Ben-Shahar,T et al. (2008)
Eco1-dependent cohesin acetylation during establishment of sister chromatid cohesion.
Science (New York, N.Y.) 2008 Jul;321;563-6
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, b.... more
D’Ambrosio,C et al. (2008)
Condensin-Dependent rDNA Decatenation Introduces a Temporal Pattern to Chromosome Segregation
Current Biology 2008 Jul;18;1084-9
The chromosomal condensin complex gives metaphase chromosomes structural stability. In addition, condensin is required for sister-chromatid resolution during their segregation in anaphase [1-7]. How c.... more
Papaemmanuil,E et al. (2008)
Deciphering the genetics of hereditary non-syndromic colorectal cancer
European Journal of Human Genetics 2008 Jul
Previously we have localized to chromosome 3q21–q24, a predisposition locus for colorectal cancer (CRC), through a genome-wide linkage screen (GWLS) of 69 families without familial adenomatous polyp.... more
pubmed   full text
Chapman,E et al. (2008)
Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells.
Molecular cancer research : MCR 2008 Jul;6;1154-68
The expression of hTERT, the catalytic subunit of telomerase, immortalizes normal human urothelial cells (NHUC). Expression of a modified hTERT, without the ability to act in telomere maintenance, did.... more
Crabb,S et al. (2008)
Characterisation of the in vitro activity of the depsipeptide histone deacetylase inhibitor spiruchostatin A.
Biochemical pharmacology 2008 Jun
We recently completed the total synthesis of spiruchostatin A, a depsipeptide natural product with close structural similarities to FK228, a histone deacetylase (HDAC) inhibitor (HDI) currently being .... more
Ekerot,M et al. (2008)
Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter.
The Biochemical journal 2008 Jun;412;287-98
DUSP6 (dual-specificity phosphatase 6), also known as MKP-3 [MAPK (mitogen-activated protein kinase) phosphatase-3] specifically inactivates ERK1/2 (extracellular-signal-regulated kinase 1/2) in vitro.... more
pubmed   full text
Vias,M et al. (2008)
Pro-neural transcription factors as cancer markers.
BMC medical genomics 2008 May;1;1-17
ABSTRACT: BACKGROUND: The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For exampl.... more
Debernardi,S et al. (2008)
Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia.
PLOS One 2008 May;3
Acute myeloid leukaemia (AML) is the most common acute leukaemia in adults; however, the genetic aetiology of the disease is not yet fully understood. A quantitative expression profile analysis of 157.... more
pubmed   full text
Paulsson,K et al. (2008)
Microdeletions are a general feature of adult and adolescent acute lymphoblastic leukemia: unexpected similarities with pediatric disease
Proceedings of the National Academy of Sciences 2008 May;105;6708-13
We present here a genome-wide map of abnormalities found in diagnostic samples from 45 adults and adolescents with acute lymphoblastic leukemia (ALL). 500K single nucleotide polymorphism (SNP) array a.... more
pubmed   full text
Fasano,C et al. (2008)
Gene expression profile of quinacrine-cured prion-infected mouse neuronal cells.
Journal of Neurochemistry 2008 Apr;105;239-250
Prion diseases are transmissible fatal neurodegenerative diseases of humans and animals, characterised by the presence of an abnormal isoform (scrapie prion protein; PrP(Sc)) of the endogenous cellula.... more
pubmed   full text
Noel,E et al. (2008)
Identification of Genomic Changes Associated with Cisplatin Resistance in Testicular Germ Cell Tumor Cell Lines.
Genes, Chromosomes & Cancer 2008 Apr;47;604-13
Since the introduction of cisplatin into the clinic, the treatment of patients with a variety of solid tumors including testicular germ cell tumors, ovarian and lung cancers, has dramatically improv.... more
pubmed   full text
Tomlinson,I et al. (2008)
A genome-wide association study identifies novel colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3
Nature Genetics 2008 Apr
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study: Phase 1 was based on genotyping 550,163 tagging single nucleotide polymorphisms (tagSNPs) in 9.... more
pubmed   full text
Jones,A et al. (2008)
A comprehensive genetic profile of phyllodes tumours of the breast detects important mutations, intra-tumoral genetic heterogeneity and new genetic changes on recurrence.
The Journal of pathology 2008 Jan;214;533-544
The aims of this study were to identify genetic changes associated with malignant progression of the fibroepithelial neoplasms, phyllodes tumours of the breast (PTs), and to ascertain whether genetic .... more
pubmed   full text
Segditsas,S et al. (2008)
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
Human molecular genetics 2008 Jan
In order to identify new genes with differential expression in early intestinal tumours, we performed mRNA expression profiling of 16 human and 63 mouse adenomas. All individuals had germline APC muta.... more
Jaegger,E et al. (2008)
Common genetic variants at the HMPS/CRAC1 locus on chromosome 15q13.3 influence the risk of colorectal cancer in the UK population
Nature Genetics 2008 Jan;40;26-28
We mapped a high-penetrance gene (CRAC1; also known as HMPS) associated with colorectal cancer (CRC) in the Ashkenazi population to a 0.6-Mb region on chromosome 15 containing SCG5 (also known as SGNE.... more
pubmed   full text
Broderick,P et al. (2007)
A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk
Nature Genetics 2007 Oct;39;1315-1317
To identify risk variants for colorectal cancer (CRC), we conducted a genome-wide association study, genotyping 550,163 tag SNPs in 940 individuals with familial colorectal tumor (627 CRC, 313 advance.... more
pubmed   full text
Tomlinson,I et al. (2007)
A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21.
Nature genetics 2007 Aug;39;984-8
Much of the variation in inherited risk of colorectal cancer (CRC) is probably due to combinations of common low risk variants. We conducted a genome-wide association study of 550,000 tag SNPs in 930 .... more
Delpuech,O et al. (2007)
Induction of Mxi1-SR alpha by FOXO3a contributes to repression of Myc-dependent gene expression.
Molecular and cellular biology 2007 Jul;27;4917-30
Forkhead transcription factors of the O class (FOXOs) are important targets of the phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway. FOXOs have been implicated in the regulation of cell cycle pr.... more
Swanton,C et al. (2007)
Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs.
Cell cycle (Georgetown, Tex.) 2007 Jun;6;2001-4
The sequential use of non cross-resistant cytotoxic agents is the standard of care for advanced solid tumors in order to enhance survival and optimise quality of life. Nevertheless, drug resistance to.... more
Swanton,C et al. (2007)
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs.
Cancer cell 2007 Jun;11;498-512
Cytotoxic drug resistance is a major cause of cancer treatment failure. We report an RNA interference screen to identify genes influencing sensitivity of different cancer cell types to chemotherapeuti.... more
Ramjaun,A et al. (2007)
Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosis.
Oncogene 2007 Feb;26;970-81
Transforming growth factor-beta (TGFbeta)-activated signalling pathways can lead to apoptosis, growth arrest or promotion of malignant behaviour, dependent on cellular context. The molecular mechanism.... more
Harada,T et al. (2007)
Identification of genetic alterations in pancreatic cancer by the combined use of tissue microdissection and array-based comparative genomic hybridisation.
British journal of cancer 2007 Jan;96;373-82
Pancreatic ductal adenocarcinoma (PDAC) is characterised pathologically by a marked desmoplastic stromal reaction that significantly reduces the sensitivity and specificity of cytogenetic analysis. To.... more
Pollard,P et al. (2006)
Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations.
The Journal of clinical endocrinology and metabolism 2006 Nov;91;4593-8
CONTEXT: Activation of the hypoxia-inducible transcription factors HIF-1 and HIF-2 and a HIF-independent defect in developmental apoptosis have been implicated in the pathogenesis of pheochromocytoma .... more
Kemp,Z et al. (2006)
Evidence for a colorectal cancer susceptibility locus on chromosome 3q21-q24 from a high-density SNP genome-wide linkage scan.
Human molecular genetics 2006 Oct;15;2903-10
To identify a novel susceptibility gene for colorectal cancer (CRC), we conducted a genome-wide linkage analysis of 69 pedigrees segregating colorectal neoplasia in which involvement of known loci had.... more
Sieber,O et al. (2006)
Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.
Gut 2006 Oct;55;1440-1448
BACKGROUND: Attenuated familial adenomatous polyposis (AFAP) is associated with germline mutations in the 5', 3', and exon 9 of the adenomatous polyposis coli (APC) gene. These mutations probably enco.... more
Redd,M et al. (2006)
Imaging macrophage chemotaxis in vivo: studies of microtubule function in zebrafish wound inflammation.
Cell motility and the cytoskeleton 2006 Jul;63;415-22
The inflammatory response is one of the most dramatic examples of directed cell movement in nature. Inflammation is triggered at the site of injury and results in the migration of immune cells to the .... more
Mulholland,P et al. (2006)
Genomic profiling identifies discrete deletions associated with translocations in glioblastoma multiforme.
Cell cycle (Georgetown, Tex.) 2006 Apr;5;783-91
Glioblastoma multiforme is the most common tumor arising in the central nervous system. Patients with these tumors have limited treatment options and their disease is invariably fatal. Molecularly tar.... more
Poolman,M et al. (2006)
Challenges to be faced in the reconstruction of metabolic networks from public databases.
Systems biology 2006 Jan;153;379-84
In the post-genomic era, the biochemical information for individual compounds, enzymes, reactions to be found within named organisms has become readily available. The well-known KEGG and BioCyc databa.... more
Taussig,D et al. (2005)
Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia.
Blood 2005 Dec;106;4086-92
Human hematopoietic stem cells (HSCs) are generally regarded as being devoid of the markers expressed by differentiated blood cells, the lineage-specific antigens. However, recent work suggests that g.... more
Wood,R et al. (2005)
Human DNA repair genes, 2005.
Mutation research 2005 Sep;577;275-83
An updated inventory of about 150 human DNA repair genes is described. The compilation includes genes encoding DNA repair enzymes, some genes associated with cellular responses to DNA damage, and othe.... more
Pollard,P et al. (2005)
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
Human molecular genetics 2005 Aug;14;2231-9
The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour suppressors. Germline mutations in FH predispose individuals to leiomyomas.... more
Sieber,O et al. (2005)
Tissue, cell and stage specificity of (epi)mutations in cancers.
Nature reviews. Cancer 2005 Aug;5;649-55
Most (epi)mutations in cancers are specific to particular tumours or occur at specific stages of development, cell differentiation or tumorigenesis. Simple molecular mechanisms, such as tissue-restric.... more
Lengronne,A et al. (2004)
Cohesin relocation from sites of chromosomal loading to places of convergent transcription.
Nature 2004 Jul;430;573-8
Sister chromatids, the products of eukaryotic DNA replication, are held together by the chromosomal cohesin complex after their synthesis. This allows the spindle in mitosis to recognize pairs of repl.... more
Schulze,A et al. (2004)
The transcriptional response to Raf activation is almost completely dependent on Mitogen-activated Protein Kinase Kinase activity and shows a major autocrine component.
Molecular biology of the cell 2004 Jul;15;3450-63
The Raf protein kinases are major effectors of Ras GTPases and key components of the transcriptional response to serum factors, acting at least in part through the extracellular signal-regulated kinas.... more
Choudhury,A et al. (2004)
Molecular analysis of peroxisome proliferation in the hamster.
Toxicology and applied pharmacology 2004 May;197;9-18
Three novel P450 members of the cytochrome P450 4A family were cloned as partial cDNAs from hamster liver, characterised as novel members of the CYP4A subfamily, and designated CYP4A17, 18, and 19. Ha.... more
Mee,C et al. (2004)
Latrophilin is required for toxicity of black widow spider venom in Caenorhabditis elegans.
The Biochemical journal 2004 Feb;378;185-91
Black widow spider venom (BWSV) kills Caenorhabditis elegans after injection owing to the presence of heat- and detergent-sensitive components, which are high-molecular-mass latrotoxins. A C. elegans .... more
Jiménez,J et al. (2003)
Microarray analysis of orthologous genes: conservation of the translational machinery across species at the sequence and expression level.
Genome biology 2003 Dec;4;R4
BACKGROUND: Genome projects have provided a vast amount of sequence information. Sequence comparison between species helps to establish functional catalogues within organisms and to study how they are.... more
Jiménez,J et al. (2003)
Functional recycling of C2 domains throughout evolution: a comparative study of synaptotagmin, protein kinase C and phospholipase C by sequence, structural and modelling approaches.
Journal of molecular biology 2003 Oct;333;621-39
The C2 domain is one of the most frequent and widely distributed calcium-binding motifs. Its structure comprises an eight-stranded beta-sandwich with two structural types as if the result of a circula.... more
Jones,L et al. (2003)
Cryptic rearrangement involving MLL and AF10 occurring in utero.
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K 2003 Aug;17;1667-9
Edwards,A et al. (2003)
Relationships among murine CD11c(high) dendritic cell subsets as revealed by baseline gene expression patterns.
Journal of immunology (Baltimore, Md. : 1950) 2003 Jul;171;47-60
The functional relationships and properties of different subtypes of dendritic cells (DC) remain largely undefined. To better characterize these cells, we used global gene analysis to determine gene e.... more
Debernardi,S et al. (2003)
Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events.
Genes, chromosomes & cancer 2003 Jun;37;149-58
Gene expression profiles were determined from presentation peripheral blood and bone marrow samples of 28 patients with acute myeloid leukemia (AML). Hierarchical clustering sorted the profiles into s.... more
Alam,N et al. (2003)
Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency.
Human molecular genetics 2003 Jun;12;1241-52
Germline mutations of the fumarate hydratase (FH, fumarase) gene are found in the recessive FH deficiency syndrome and in dominantly inherited susceptibility to multiple cutaneous and uterine leiomyom.... more
Hao,X et al. (2002)
The spectrum of p53 mutations in colorectal adenomas differs from that in colorectal carcinomas.
Gut 2002 Jun;50;834-9
BACKGROUND: p53 mutations are frequently observed in colorectal carcinomas but they have also been found in colorectal adenomas, although considerably less frequently. AIMS: To explore p53 mutations i.... more
Wood,V et al. (2002)
The genome sequence of Schizosaccharomyces pombe.
Nature 2002 Feb;415;871-80
We have sequenced and annotated the genome of fission yeast (Schizosaccharomyces pombe), which contains the smallest number of protein-coding genes yet recorded for a eukaryote: 4,824. The centromeres.... more
Iglesias,T et al. (2000)
Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.
The Journal of biological chemistry 2000 Dec;275;40048-56
Protein kinase D (PKD) is a serine/threonine kinase regulated by diacylglycerol signaling pathways with unique domain composition and enzymatic properties, still awaiting identification of its specifi.... more
Brown,A et al. (2000)
c-abl is involved in the association of p53 and trk A.
Oncogene 2000 Jun;19;3032-40
The p53 tumour suppressor phosphoprotein associates with proteins involved in DNA replication, transcription, cell cycle machinery and regulation of its own expression. Recently it has been shown that.... more
Paige,A et al. (2000)
A 700-kb physical map of a region of 16q23.2 homozygously deleted in multiple cancers and spanning the common fragile site FRA16D.
Cancer research 2000 Mar;60;1690-7
We have identified a >600-kb region at 16q23.2 that is homozygously deleted from malignant ovarian ascites using representational difference analysis. Overlapping homozygous deletions were also observ.... more
Karimi-Busheri,F et al. (1999)
Molecular characterization of a human DNA kinase.
The Journal of biological chemistry 1999 Aug;274;24187-94
Human polydeoxyribonucleotide kinase is an enzyme that has the capacity to phosphorylate DNA at 5'-hydroxyl termini and dephosphorylate 3'-phosphate termini and, therefore, can be considered a putativ.... more
Höss,M et al. (1999)
A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein.
The EMBO journal 1999 Jul;18;3868-75
Mammalian DNA polymerases alpha and beta lack 3' exonuclease activity and are unable to edit errors after DNA synthesis. However, editing exonucleases can be functions of separate polypeptides. We iso.... more
Chadwick,B et al. (1999)
Cloning, mapping and expression of UBL3, a novel ubiquitin-like gene.
Gene 1999 Jun;233;189-95
A novel Drosophila melanogaster gene UBL3 was characterized and shown to be highly conserved in man and Caenorhabditis elegans (C. elegans). The human and mouse homologues were cloned and sequenced. U.... more
Jones,T et al. (1999)
A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer.
The Journal of biological chemistry 1999 May;274;15633-45
A novel human gene (PLU-1) has been identified which shows a highly restricted expression in normal adult tissues but which is consistently expressed in breast cancers. A fragment of the PLU-1 cDNA wa.... more
Sgouros,J et al. (1999)
A relationship betweena DNA-repair/recombination nuclease family and archaeal helicases.
Trends in biochemical sciences 1999 Mar;24;95-7
Schiavo,G et al. (1998)
Synaptotagmins: more isoforms than functions?
Biochemical and biophysical research communications 1998 Jul;248;1-8
Herberg,J et al. (1998)
Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC.
European journal of immunology 1998 Feb;28;459-67
The Tapasin molecule is a member of the immunoglobulin (Ig) superfamily required for the association of TAP transporters and MHC class I heterodimers in the endoplasmic reticulum. In this study, the T.... more